Low- and high-density lipoprotein subclasses in subjects with nonalcoholic fatty liver disease.
Sonmez A, et al. J Clin Lipidol. 2015 Jul-Aug.
Sonmez A1, Nikolic D2, Dogru T3, Ercin CN3, Genc H3, Cesur M4, Tapan S5, Karslioğlu Y6, Montalto G2, Banach M7, Toth PP8, Bagci S3, Rizzo M9.
Department of Endocrinology and Metabolic Diseases, Gulhane School of Medicine, Ankara, Turkey.
BioMedical Department of Internal Medicine and Medical Specialties, University of Palermo, Italy.
Department of Gastroenterology, Gulhane School of Medicine, Ankara, Turkey.
Department of Endocrinology, Ankara Guven Hospital, Ankara, Turkey.
Department of Medical Biochemistry, Gulhane School of Medicine, Ankara, Turkey.
Department of Pathology, Gulhane School of Medicine, Ankara, Turkey.
Department of Nephrology and Hypertension, Medical University of Lodz, Poland.
Department of Preventive Cardiology, CGH Medical Center, Sterling, IL, USA; Department of Family and Community Medicine, University of Illinois, School of Medicine, Peoria, IL, USA; Ciccarone Center for Cardiovascular Disease Prevention, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address: email@example.com.
BioMedical Department of Internal Medicine and Medical Specialties, University of Palermo, Italy; Euro-Mediterranean Institute of Science and Technology, Italy.
J Clin Lipidol. 2015 Jul-Aug;9(4):576-82. doi: 10.1016/j.jacl.2015.03.010. Epub 2015 Apr 4.
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is associated with increased cardiometabolic risk. Although dyslipidemia represents a key factor in this disease, its impact on serum levels of distinct lipoprotein subfractions is largely unknown.
OBJECTIVE: To assess the full low-density lipoprotein (LDL) and high-density lipoprotein (HDL) profiles in patients with NAFLD.
METHODS: Seven LDL and 10 HDL subfractions were assessed by gel electrophoresis (Lipoprint, Quantimetrix Corporation, USA) in men with biopsy proven NAFLD (simple steatosis [n = 17, age, 34 ± 7 years] and nonalcoholic steatohepatitis [NASH; n = 24, age, 32 ± 6 years]). Exclusion criteria included robust alcohol consumption, infection with hepatitis B or C virus, body mass index ≥ 40 kg/m(2), diabetes mellitus, and hypertension.
RESULTS: Compared with simple steatosis, NASH patients had similar body mass index, homeostasis model assessment of insulin resistance index and plasma lipids, with increased levels of both aspartate aminotransferase and alanine transaminase. NASH subjects had lower levels of larger LDL1 (10 ± 4 vs 13 ± 4%, P = .010) and increased smaller LDL3 and LDL4 particles (9 ± 5 vs 5 ± 5%, P = .017 and 3 ± 3 vs 1 ± 2%, P = .012, respectively). No changes were found in the HDL subclass profile. By multiple regression analysis, we found that NASH was associated only with increased levels of LDL3 (P = .0470).
CONCLUSIONS: The increased levels of small, dense LDL3 and LDL4 in NASH may help to at least partly explain the increased risk for atherosclerosis and cardiovascular diseases in these patients.
Copyright © 2015 National Lipid Association. Published by Elsevier Inc. All rights reserved.
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